5-BROMO-7-FLUORO-2,3-DIHYDRO-1H-INDOLE synthesis
- Product Name:5-BROMO-7-FLUORO-2,3-DIHYDRO-1H-INDOLE
- CAS Number:954258-03-8
- Molecular formula:C8H7BrFN
- Molecular Weight:216.05
769966-04-3
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954258-03-8
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Yield:954258-03-8 83.4 %
Reaction Conditions:
with N-Bromosuccinimide in acetonitrile at 20;
Steps:
46.2 The second step:
Compound 132a (1.5g, 10.94mmol, 1equiv.) was added in acetonitrile (80mL), and N-bromosuccinimide (1.95g, 10.94mmol, 1equiv.) was added dropwise under ice bath Acetonitrile solution (15 mL), react at room temperature for 2 hours.LCMS showed that the reaction was complete. The solvent was spin-dried and separated by flash silica gel chromatography (PE:EA=33:1) to obtain compound 132b (1.97 g, yield: 83.4%).
References:
CN115353512,2022,A Location in patent:Paragraph 0461-0463; 0465
387-44-0
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954258-03-8
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