5-BROMO-6-(CHLOROMETHYL)-1,3-BENZODIOXOLE synthesis

5synthesis methods

Product Name:5-BROMO-6-(CHLOROMETHYL)-1,3-BENZODIOXOLE
CAS Number:64603-67-4
Molecular formula:C8H6BrClO2
Molecular Weight:249.49

20850-43-5
159 suppliers
$17.67/1gm:

5-BROMO-6-(CHLOROMETHYL)-1,3-BENZODIOXOLE

64603-67-4
17 suppliers
inquiry

Yield:64603-67-4 99%

Reaction Conditions:

with N-Bromosuccinimide in acetonitrile at 20; for 13 h;Inert atmosphere;

Steps:

10.1 Preparation of 5-bromo-6- (chloromethyl) benzo [d] [1,3] dioxole

In step (1) of Example 9 under an argon atmosphereThe resulting 5- (chloromethyl) benzo [d] [1,3] dioxole (2.29 g, 13.42 mmol) was dissolved in acetonitrile (27 mL), and N-bromosuccinimide (2.39 g, 16.11 mmol ) Was added. The reaction solution was stirred at room temperature for 13 hours, and the completion of the reaction was confirmed by TLC (hexane: ethyl acetate = 2: 1). After the reaction mixture was poured into water, the organic solvent layer extracted with dichloromethane (10 mL x 3) was washed again with saturated sodium chloride solution (50 mL), and the organic solvent layer was dried over anhydrous magnesium sulfate, filtered and concentrated under reduced pressure to remove the solvent . The concentrate was separated and purified by column chromatography (hexane: ethyl acetate = 5: 1) to obtain the desired compound (3.32 g, 99% yield).

References:

KR2016/59366,2016,A Location in patent:Paragraph 0303; 0304; 0305; 0306

495-76-1 Synthesis