Yield:852180-52-0 89%

Reaction Conditions:

Stage #1: 5-bromobenzo[b]thiophene-3-carboxylic acidwith triethylamine;isobutyl chloroformate in tetrahydrofuran at 0;
Stage #2: with sodium tetrahydroborate in tetrahydrofuran;water at 0 - 20;

References:

Santillan Jr., Alejandro;McClure, Kelly J.;Allison, Brett D.;Lord, Brian;Boggs, Jamin D.;Morton, Kirsten L.;Everson, Anita M.;Nepomuceno, Diane;Letavic, Michael A.;Lee-Dutra, Alice;Lovenberg, Timothy W.;Carruthers, Nicholas I.;Grice, Cheryl A. [Bioorganic and Medicinal Chemistry Letters,2010,vol. 20,# 21,p. 6226 - 6230] Location in patent:scheme or table