5-amino-2-(4-amino-2-hydroxy-phenyl)phenol synthesis
- Product Name:5-amino-2-(4-amino-2-hydroxy-phenyl)phenol
- CAS Number:70894-13-2
- Molecular formula:C12H12N2O2
- Molecular Weight:216.2359
554-84-7
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Yield:70894-13-2 70%
Reaction Conditions:
with water;sodium hydroxide;zinc in ethanol; for 10 h;Inert atmosphere;
Steps:
1.1.2 Preparation of 4,4'-diamino- [1,1'-biphenyl] -2,2'-diol (CLC-1.1):
To a mixture of 3-nitrophenol (6.95 g, 0.05 mol) (Aldrich) in ethanol (50 ml) (Aldrich) was added a 12 M aqueous NaOH solution (25 ml) (Aldrich) and zinc powder (13 g, 0.2 mol) ( Aldrich) was added under a nitrogen atmosphere (Airgas, San Marcos, CA, USA).The resulting mixture was stirred for 10 hours and then filtered.The filtrate was acidified with acetic acid (Aldrich) to pH 4 and a precipitate formed.The solid is collected by filtration, washed with water until neutral,Vacuum oven (Thermo Scientific Precision)6500, Thermo Fisher Scientific Waltham, Mass. USA at 60 ° C. and 2 Torr vacuum drying to give the desired product (3.8 g, 70% yield).), That is, CLC-1.1 was obtained.This compound was characterized by LCMS:
References:
JP2019/532064,2019,A Location in patent:Paragraph 0078
2050-15-9
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70894-13-2
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99-09-2
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