ChemicalBook CAS DataBase List 4-(TRIFLUOROMETHYL)QUINOLINE

4-(TRIFLUOROMETHYL)QUINOLINE synthesis

7synthesis methods

Product Name:4-(TRIFLUOROMETHYL)QUINOLINE
CAS Number:25199-77-3
Molecular formula:C10H6F3N
Molecular Weight:197.16

2806-29-3 Synthesis

2806-29-3
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$65.00/100mg

25199-77-3
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$121.00/0.25 / G

Yield: 47%

Reaction Conditions:

with triethylsilane;bis-triphenylphosphine-palladium(II) chloride in acetonitrile at 70; for 18 h;

Steps:

100 General Procedure 100: 4-Trifluoromethyl-quinoline (Intermediate 467)
General Procedure 100: 4-Trifluoromethyl-quinoline (Intermediate 467)Pd (PPh3)2Cl2 (170 mg, 0.24 mmol) and triethylsilane (5.4 ml, 33.9 mmol) were added to a solution of 2-chloro-4-trifluoromethyl-quinoline 466 (5.60 g, 24.2 mmol) in MeCN (3 ml) and the mixture was heated at 70° C. for 18 h. The solvent was removed in vacuo. The crude residue was purified by column chromatography with n-hexane/EtOAc (95:5) to give the title compound (2.2 g, 47%).MW: 197HPLCMS (Method C):[m/z]: 198

References:

VIFOR (INTERNATIONAL) AG US2012/214803, 2012, A1 Location in patent:Page/Page column 172

590372-17-1 Synthesis