ChemicalBook CAS DataBase List 4-TOLUENESULFONYLACETIC ACID

4-TOLUENESULFONYLACETIC ACID synthesis

14synthesis methods

Product Name:4-TOLUENESULFONYLACETIC ACID
CAS Number:3937-96-0
Molecular formula:C9H10O4S
Molecular Weight:214.24

3996-29-0
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3937-96-0
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$21.21/1gm:

Yield: 85.1%

Reaction Conditions:

with dihydrogen peroxide;acetic acid at 45 - 90; for 15 h;

Steps:

1.2 (2) Preparation of intermediate 2
Intermediate 1 (3.00 g, 16.48 mmol) was dissolved in 50 mL glacial acetic acid and stirred magnetically.Slowly add 6mL of 30% H2O2 (diluted with 10mL glacial acetic acid) at 45 °C.The temperature was raised to 70 ° C for 4 h, and then the temperature was raised to 90 ° C for 11 h.After the reaction was stopped, about 130 mL of water was added to the reaction mixture, and the mixture was extracted with ethyl acetate (yield: 80 mL × 3) and concentrated.Separated and purified by DCM:MeOH=60:1 column chromatography.3.00 g of a white solid was obtained in a yield of 85.1%.

References:

Southeast University;Fang Lei;Xu Fangze CN110037989, 2019, A Location in patent:Paragraph 0037; 0043-0047

106-45-6 Synthesis