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619-91-0

(4-Nitroanilino)acetic acid synthesis

8synthesis methods
-

Yield:619-91-0 95%

Reaction Conditions:

with D-myo-inositol;copper;caesium carbonate in water at 100; for 8 h;Reagent/catalyst;

Steps:



The reaction of 1-bromo-4-nitrobenzene (0.20 g, 1.0mmol), glycine (0.112 g, 1.5 mmol), copper powder (0.0064 g, 0.1 mmol), MI (0.036g, 0.2 mmol), Cs2CO3 (0.977 g, 3.0 mmol), TBAHS (0.068 g, 0.2 mmol) produced0.186 g (95%) of (4-nitrophenyl)glycine as a brown solid.

References:

Zhou, Qifan;Du, Fangyu;Chen, Yuanguang;Fu, Yang;Chen, Guoliang [Tetrahedron Letters,2019,vol. 60,# 29,p. 1938 - 1941] Location in patent:supporting information

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