ChemicalBook CAS DataBase List 4-N-BUTOXYBENZONITRILE

4-N-BUTOXYBENZONITRILE synthesis

14synthesis methods

Product Name:4-N-BUTOXYBENZONITRILE
CAS Number:5203-14-5
Molecular formula:C11H13NO
Molecular Weight:175.23

623-00-7
472 suppliers
$6.00/10g

71-36-3 Synthesis

71-36-3
1044 suppliers
$14.00/25mL

5203-14-5
58 suppliers
$45.00/100mg

Yield: 92%

Reaction Conditions:

with nickel(II) sulfate hexahydrate;4,4'-Dimethoxy-2,2'-bipyridin;C₄₁H₄₀O₁₆;N-ethyl-N,N-diisopropylamine in N,N-dimethyl-formamide;acetonitrile for 24 h;Inert atmosphere;Microwave irradiation;

Steps:

10 [Example 10]
Add the photocatalyst prepared in Example 1 (0.002mmol), nickel(II) sulfate hexahydrate (0.02mmol), 4,4'-dimethoxy-2,2'-bipyridine (0.02mmol), 4 -Bromobenzonitrile (36.4mg, 0.2mmol), N,N-diisopropylethylamine (0.3mmol), n-butanol (8mmol), DMF and acetonitrile (1:1, 1mL), after nitrogen protection Reaction for 24 hours under 23W CFL irradiation. Finally, the reaction solution was concentrated using a rotary evaporator, and quickly separated by 200-300 mesh silica gel column chromatography. The eluent used was ethyl acetate/petroleum ether (v:v=1:5). The product quality was calculated to obtain 4- The yield of n-butoxybenzonitrile was 92%.

References:

Jiangnan University;Rao Yijian;Yuan Zhenbo;Zhang Yan;Liu Changmei;Li Min CN111848570, 2020, A Location in patent:Paragraph 0079-0081