ChemicalBook CAS DataBase List (4-METHYLPHENYL)-1-(2H)-PHTHALAZINONE

(4-METHYLPHENYL)-1-(2H)-PHTHALAZINONE synthesis

11synthesis methods

Product Name:(4-METHYLPHENYL)-1-(2H)-PHTHALAZINONE
CAS Number:51334-85-1
Molecular formula:C15H12N2O
Molecular Weight:236.27

85-55-2
119 suppliers
$10.00/5g

51334-85-1
30 suppliers
$125.00/25g

Yield:51334-85-1 86%

Reaction Conditions:

with hydrazine hydrate in toluene;Reflux;

Steps:

Reaction of 2-(p-toluoyl)benzoic acid 1 with hydrazines to givephthalazines 2a-d; general procedure

General procedure: A solution of 2-(p-toluoyl)benzoic acid 1 (2 mmol) in dry toluene(30 mL) and an equivalent amount of hydrazine hydrate, phenylhydrazine, 2-pyridyl hydrazine or thiosemicarbazide was refluxed for3-4 h. The solid product formed during the reaction was filtered off, washed with light petroleum ether and recrystallised from a suitablesolvent to give compounds 2a-d.

References:

Hemdan, Magdy M.;Taha, Sherif M.;Gabr, Adel M.;Elkady, Mohamed Y. [Journal of Chemical Research,2014,vol. 38,# 10,p. 617 - 621]