ChemicalBook CAS DataBase List 4-Methoxytriphenylmethyl chloride

4-Methoxytriphenylmethyl chloride synthesis

9synthesis methods

Product Name:4-Methoxytriphenylmethyl chloride
CAS Number:14470-28-1
Molecular formula:C20H17ClO
Molecular Weight:308.8

847-83-6
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$48.29/10g

14470-28-1
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$9.00/5g

Yield:14470-28-1 89.1%

Reaction Conditions:

with hydrogenchloride in toluene at 15 - 30;Solvent;Temperature;

Steps:

1; 2; 3; 4; 5 Example 1

MHT-OH 290 g (1 mol) and toluene 900 g were placed in a four-neck reaction flask, and the temperature was lowered to 15 ° C to start stirring. With hydrogen chloride, the reaction temperature does not exceed 30 ° C when ventilated. During the aeration process, TLC monitors the progress of the reaction. After the raw material is completely reacted, about 50 g of hydrogen chloride is introduced. The reaction solution was concentrated under reduced pressure at 40-65 ° C until almost no liquid, and 350 g of tert-butyl ether was added. Cool down to 10-25 °C. The mixture was stirred for 1 hour, filtered under reduced pressure, and the filter cake was washed once with 100 ml of petroleum ether. The infrared lamp is dried at 50-55 ° C, and the white crystal is 275 g. The yield was 89.1%, and the HPLC purity was 98% or more.

References:

CN109761763,2019,A Location in patent:Paragraph 0030-0040

119-61-9 Synthesis