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ChemicalBook CAS DataBase List 4-METHOXYPYRIDINE-2-CARBOXYLIC ACID
29082-91-5

4-METHOXYPYRIDINE-2-CARBOXYLIC ACID synthesis

4synthesis methods
-

Yield:-

Steps:

Multi-step reaction with 4 steps
1: 2 h / 65 - 70 °C
2: 73 percent / H2O / -8 - -7 °C
3: 1.) 90percent H2SO4, 2.) NaNO2 / 1.) 120 deg C, 2 h, 2.) water, 20-25 deg C, 1 h, then 80 deg C, 1 h
4: 90 percent / Na / 2 h / Heating

References:

Desjardins, Sylvie Y.;Cavell, Kingsley J.;Hoare, Jason L.;Skelton, Brian W.;Sobolev, Alexander N.;White, Allan H.;Keim, Wilhelm [Journal of Organometallic Chemistry,1997,vol. 544,# 2,p. 163 - 174]

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