ChemicalBook CAS DataBase List 4'-Isopropylacetophenone

4'-Isopropylacetophenone synthesis

13synthesis methods

Product Name:4'-Isopropylacetophenone
CAS Number:645-13-6
Molecular formula:C11H14O
Molecular Weight:162.23

By condensing cymene with acetyl chloride in the presence of AlCl3; also from benzol, acetyl chloride and isopropyl chloride via Friedel–Craft

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645-13-6
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Yield:645-13-6 91%

Reaction Conditions:

with monoethylene glycol diethyl ether at 90; for 12 h;Green chemistry;

Steps:

2.1 General Procedure for the Synthesis of Ketones 2 with air

General procedure: A mixture of alkene 1 (0.6 mmol), 1,2-diethoxyethane (0.5 mL, 3.6 mmol) was added to a 5 mL round-bottom flask with an air balloon at room temperature, then the contents were stirred at 90 °C for 12 hours. The progress of the reaction was monitored by TLC or GC-MS. Upon completion, the reaction was cooled down to room temperature. The resultant residue was purified by silica gel column chromatography to afford the desired product 2.

References:

Liu, Kai-Jian;Deng, Ji-Hui;Zeng, Tang-Yu;Chen, Xin-Jie;Huang, Ying;Cao, Zhong;Lin, Ying-Wu;He, Wei-Min [Chinese Chemical Letters,2020,vol. 31,# 7,p. 1868 - 1872] Location in patent:supporting information

2055-40-5 Synthesis