(4-Iodophenyl)acetyl choride synthesis
- Product Name:(4-Iodophenyl)acetyl choride
- CAS Number:37051-38-0
- Molecular formula:C8H6ClIO
- Molecular Weight:280.49
1798-06-7
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37051-38-0
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Yield:37051-38-0 100%
Reaction Conditions:
with thionyl chloride for 2 h;Heating;Inert atmosphere;
Steps:
3
A mixture of 4-iodophenylacetic acid (3 g, 11.5 mmol, 1 e.q.) and thionyl chloride (5 mL, 49 mmol, 4.5 e.q.) was heated in an 80 °C oil bath under argon for 2 h. The reaction is then allowed to cool to room temperature. The excess thionyl chloride is removed in vacuum to give 6 as a dark yellow oil (3.2 g, 100%) which is used without further purification. NMR (300 MHz, CDCb) d 4.11 (2 H, s, CH2), 7.03 & 7.73(4 H, AA'XX', Ph-H).
References:
WO2021/62491,2021,A1 Location in patent:Paragraph 00194
1798-06-7
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84863-81-0
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37051-38-0
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1197-55-3
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37051-38-0
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