ChemicalBook CAS DataBase List 4-IODO-2,5-DIMETHOXYPHENETHYLAMINE

4-IODO-2,5-DIMETHOXYPHENETHYLAMINE synthesis

10synthesis methods

Product Name:4-IODO-2,5-DIMETHOXYPHENETHYLAMINE
CAS Number:69587-11-7
Molecular formula:C10H14INO2
Molecular Weight:307.13

Ethanamine, N-[(3,5-dichlorophenyl)methylene]-2,2-diethoxy-

1000210-73-0
0 suppliers
inquiry

69587-11-7
1 suppliers
inquiry

Yield: 99%

Reaction Conditions:

with trifluoroacetic acid in dichloromethane at 20; for 1 h;

Steps:

4.2.17. 2-(((4-iodo-2,5-dimethoxyphenethyl)amino)methyl)phenol(19)
4.2.17.1. Deprotection of 18b. TFA (1.35 mL) was added dropwise toa solution of compound 18b (367 mg, 0.902 mmol) in DCM (1.5 mL).The reaction mixture was left to stir at room temperature for about1 h. When the reaction was completed according to LC-MS thesolvent was evaporated in vacuum and saturated NaHCO3 (aq.) wasadded to adjust the pH to around 8e9. The product was thenextracted using DCM (3 10 mL) and the solvent was removed invacuum to give the amine (275 mg, 99% yield). The amine was usedfurther for the synthesis of compound 19 and 21b.

References:

Wu, Xiongyu;Eriksson, Caroline;Wohlfarth, Ariane;Wallgren, Jakob;Kronstrand, Robert;Josefsson, Martin;Dahlén, Johan;Konradsson, Peter [Tetrahedron,2017,vol. 73,# 45,p. 6393 - 6400]

159277-10-8 Synthesis