ChemicalBook CAS DataBase List 4-hydroxy-6-nitroquinolin-2(1H)-one

4-hydroxy-6-nitroquinolin-2(1H)-one synthesis

8synthesis methods

Product Name:4-hydroxy-6-nitroquinolin-2(1H)-one
CAS Number:264260-06-2
Molecular formula:C9H6N2O4
Molecular Weight:206.15

125600-42-2 Synthesis

125600-42-2
9 suppliers
inquiry

124-38-9
129 suppliers
$214.00/14L

264260-06-2
14 suppliers
inquiry

Yield:264260-06-2 80%

Reaction Conditions:

with 1,1,3,3-tetramethylguanidinium imidazolide;silver nitrate at 60; under 750.075 Torr; for 2 h;

Steps:

19

Weigh out 2-ethynyl-4-nitroaniline (1mmol), silver nitrate (0.02mmol) and [HTMG][Im] (3mmol) into a 20mL reaction tube, which is equipped with a stir bar and the reaction tube Placed on a magnetic stirrer, the mouth of the reaction tube is connected with a gas bag filled with carbon dioxide, and under the protection of the carbon dioxide bag (the CO₂pressure during the reaction is about 0.1 MPa), the reaction is stirred at 60°C for 2 hours. After the reaction is finished, cool to room temperature, add 10mL water, 1mol/L dilute nitric acid to adjust the pH to 6~7, precipitate a yellow solid, filter, wash with water (10mL×3), wash with methyl tert-butyl ether (10mL×3), and dry The target product 4-hydroxy-6-nitroquinoline-2(1H)-one was obtained with a yield of 80%.

References:

CN113416166,2021,A Location in patent:Paragraph 0076-0078