4-ETHOXY-2-NITROPHENYL ISOCYANATE 97 synthesis
- Product Name:4-ETHOXY-2-NITROPHENYL ISOCYANATE 97
- CAS Number:108128-49-0
- Molecular formula:C9H8N2O4
- Molecular Weight:208.17
Yield:-
Reaction Conditions:
in ethyl acetate; for 16 h;Reflux;
Steps:
86.2 Step 2: 4-Ethoxy-1-isocyanato-2-nitrobenzene .
To a stirring solution of EtOAc (100 mL) at 0 °C was added diphosgene (1.53 mL, 12.8 mmol) followed by slow addition of 4-ethoxy-2-nitroaniline (3.10 g, 17.0 mmol) dissolved in a minimal amount of EtOAc. The resulting mixture was stirred at reflux for 16 hrs and the solvents were evaporated. The resulting crude material was stirred in a 20: 1 mixture of Hexanes: EtOAc at 60 °C for 1 hr and then filtered through filter paper. The filtrate was evaporated to afford 4-ethoxy-1-isocyanato-2-nitrobenzene which was carried on to the next step.
References:
WO2017/192304,2017,A1 Location in patent:Paragraph 0300
610-81-1
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