ChemicalBook CAS DataBase List 4'-Chloropropiophenone

4'-Chloropropiophenone synthesis

9synthesis methods

Product Name:4'-Chloropropiophenone
CAS Number:6285-05-8
Molecular formula:C9H9ClO
Molecular Weight:168.62

79-03-8 Synthesis

79-03-8
411 suppliers
$9.00/1g

108-90-7
656 suppliers
$10.00/25G

6285-05-8
339 suppliers
$9.00/25g

Yield:6285-05-8 96.5%

Reaction Conditions:

with Aluminum Chloride in dichloromethane at 10 - 25; for 2 h;Solvent;Temperature;Reagent/catalyst;

Steps:

1 Example 1

Chlorobenzene (0.1 mol), with stirring,Dichloromethane (100 mL) and anhydrous aluminum trichloride (0.12 mol)Add to the reaction vessel.Temperature 10 ° C,Propionyl chloride (0.11 mol) was added dropwise slowly.After the addition is completed, the temperature is raised to 25 ° C for 2 hr.TLC detects chlorobenzene without residue,Stop the reaction,Filtering,Collecting mother liquor,The mother liquor was successively treated with 5% citric acid (100 ml).Wash with saturated sodium bicarbonate (100 ml) and saturated brine.Dry over anhydrous sodium sulfate,Then concentrate the mother liquor,Obtained a white solid,Collecting solids,Melting point 35~37 °C,The yield is 96.5 % based on chlorobenzene.The purity of HPLC was 98.9%.This solid is p-chloropropiophenone.

References:

CN108752229,2018,A Location in patent:Paragraph 0018; 0022; 0026; 0030; 0034