ChemicalBook CAS DataBase List (4-CHLOROPHENYLTHIO)ACETONE

(4-CHLOROPHENYLTHIO)ACETONE synthesis

7synthesis methods

Product Name:(4-CHLOROPHENYLTHIO)ACETONE
CAS Number:25784-83-2
Molecular formula:C9H9ClOS
Molecular Weight:200.69

1142-19-4 Synthesis

1142-19-4
150 suppliers
$27.00/10g

598-31-2
119 suppliers
$60.00/50mg

25784-83-2
70 suppliers
$20.00/5g

Yield: 86%

Reaction Conditions:

with [{Ti(salophen)H₂O}₂O][OSO₂C₄F₉]₂;zinc in tetrahydrofuran at 20; for 3 h;Inert atmosphere;

Steps:

4.4. Typical procedure for the synthesis of a-arylthio carbonylcompounds
General procedure: Under N₂atmosphere, a solution of complex 1 (68.7 mg, 5 mol%) in THF (3.0 mL), zinc dust (80 mg, 1.2 mmol), diphenyl disulfide (109 mg, 0.5 mmol), and ethyl 2-bromoacetate (184 mg, 1.1 mmol) were added. Then the mixture was stirred for 2 h at room temperature, monitored by thin-layer chromatography (TLC). The resulting reaction mixture was diluted with diethyl ether (10 mL x 3), filtered, and evaporated, and then the residue was subjected to column chromatography using petroleum ether:ethyl acetate as eluent (30:1) to afford the pure product 6a.

References:

Wang, Lingxiao;Qiao, Jie;Wei, Jiancong;Liang, Zhiwu;Xu, Xinhua;Li, Ningbo [Tetrahedron,2020,vol. 76,# 4,art. no. 130750]