Pyrrolo[2,1-f][1,2,4]triazine, 4-chloro-5-methyl- synthesis
- Product Name:Pyrrolo[2,1-f][1,2,4]triazine, 4-chloro-5-methyl-
- CAS Number:529508-56-3
- Molecular formula:C7H6ClN3
- Molecular Weight:167.6
![Pyrrolo[2,1-f][1,2,4]triazin-4(1H)-one, 5-methyl- (9CI)](/CAS/GIF/529508-54-1.gif)
529508-54-1
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$45.00/10mg
529508-56-3
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$45.00/10mg
Yield: 82%
Reaction Conditions:
in 4-(dicyanomethylene)-2-methyl-6-(p-dimethylaminostyryl)-4H-pyran;trichlorophosphate
Steps:
1.C C.
C. Preparation of 4-Chloro-5-methyl-pyrrolo[2,1-f][1,2,4]triazine A suspension of of 5-methyl-3H-pyrrolo[2,1-f][1,2,4]triazin-4-one (2.57 gm, 17.2 mmole) in POCl3 (28 mL) was heated at 100° C. for 40 min. The excess reagent was removed under vacuum and the residue was dissolved in DCM (300 mL). This was washed with water, dried (Na2SO4), and the solvent removed. Flash chromatography on silica gel using DCM as eluent afforded the product as a yellow solid (2.38 gm, 82%). 1H-NMR (CDCl3): δ 2.63 (s, 3H), 6.74 (d, 1H, J=2 Hz), 7.74 (d, 1H, J=2 Hz), 8.05 (s, 1H).
References:
Mastalerz, Harold;Zhang, Guifen;Tarrant, James G.;Vite, Gregory D. US2003/186983, 2003, A1
529508-54-1
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$45.00/10mg
529508-56-3
56 suppliers
$45.00/10mg
5448-16-8
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$45.00/50mg
529508-56-3
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$45.00/10mg
427878-69-1
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529508-56-3
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![Pyrrolo[2,1-f][1,2,4]triazine-6-carboxylic acid, 1,4-dihydro-5-methyl-4-oxo-, ethyl ester](/CAS/GIF/427878-70-4.gif)
427878-70-4
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529508-56-3
56 suppliers
$45.00/10mg