ChemicalBook CAS DataBase List 4-CARBOXYPHENYLACETIC ACID

4-CARBOXYPHENYLACETIC ACID synthesis

12synthesis methods

Product Name:4-CARBOXYPHENYLACETIC ACID
CAS Number:501-89-3
Molecular formula:C9H8O4
Molecular Weight:180.16

5462-71-5
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$8.00/250mg

501-89-3
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$7.00/1g

Yield: 81%

Reaction Conditions:

with water;potassium hydroxide at 110; for 4 h;

Steps:

I(e).i Step i: 4-(carboxymethyl)benzoic acid
To a 25 mL round bottom flask, were added 2-(4-cyanophenyl)acetic acid (2.0 g, 0.0124 mol) and 20 mL aqueous potassium hydroxide solution (3.47 g, 0.062 mol). The reaction mixture was stirred at reflux temperature for 4 h. The reaction mixture was acidified to pH 3.0 with 3 N hydrochloric acid to get the precipitate. The precipitate was collected by filtration and dried under vacuum to get the title compound [1.8 g, 81 %]. ^{FontWeight="Bold" FontSize="10"}H NMR (400 MHz, DMSO-ife): δ 12.64 (brs, 2H), 7.88 (d, = 8.1 Hz, 2H), 7.38 (d, [M+H]⁺.

References:

AURIGENE DISCOVERY TECHNOLOGIES LIMITED;BEJUGAM, Mallesham;HOSAHALLI, Subramanya;MAHALINGAM, Natarajan WO2014/125426, 2014, A1 Location in patent:Page/Page column 39; 40