ChemicalBook CAS DataBase List 4-(Bromomethyl)phenylaceticacidphenacylester

4-(Bromomethyl)phenylaceticacidphenacylester synthesis

6synthesis methods

Product Name:4-(Bromomethyl)phenylaceticacidphenacylester
CAS Number:7398-42-7
Molecular formula:C10H11BrO2
Molecular Weight:243.1

4-(Bromomethyl)phenylaceticacidphenacylester is synthesized by reacting 4-(bromomethyl)phenylacetic acid with phenacyl bromide and potassium carbonate in chloroform.

75-77-4
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13737-36-5
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4-(Bromomethyl)phenylaceticacidphenacylester

7398-42-7
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$16.00/100mg

Yield:7398-42-7 94.3%

Reaction Conditions:

in methanol at 20; for 1 h;Inert atmosphere;

Steps:

8M.1 Synthesis of methyl 2-(4-(bromomethyl)phenyl)acetate (Compound Hm-i)
In a 100 mL round bottom flask, a solution of 2-(4-(bromomethyl)phenyl)acetic acid (2.5 g, 10.91 mmol) in MeOH (50 mL) was treated with TMSC1 (0.2 mL) under nitrogen atmosphere. The reaction mixture was stirred for 1 h at RT. Upon completion of reaction (TLC), the solvent was removed under reduced pressure. The residue obtained was dissolved in methanol and concentrated under reduced pressure to give the title compound. Yield: 2.5 g (94.3%). (0727) 1H NMR (300 MHz, CDC : δ 7.36 (d, J = 8.1 Hz, 2H), 7.26 (d, J = 8.4 Hz, 2H), 4.48 (s, 2H), 3.69 (s, 3H), 3.62 (s, 2H)

References:

MITOBRIDGE, INC.;SALK INSTITUTE BIOLOGICAL STUDIES;BAIGA, Thomas;DOWNES, Michael;EVANS, Ronald;KLUGE, Arthur;LAGU, Bharat;MIURA, Masanori;PANIGRAHI, Sunil, Kumar;PATANE, Michael;SAMAJDAR, Susanta;SENAIAR, Ramesh;TAKAHASHI, Taisuke WO2016/57660, 2016, A1 Location in patent:Page/Page column 77; 78

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67-56-1 Synthesis