ChemicalBook CAS DataBase List 4-BROMO-3-METHYLBENZHYDRAZIDE

4-BROMO-3-METHYLBENZHYDRAZIDE synthesis

4synthesis methods

Product Name:4-BROMO-3-METHYLBENZHYDRAZIDE
CAS Number:148672-43-9
Molecular formula:C8H9BrN2O
Molecular Weight:229.07

Hydrazinecarboxylic acid, 2-(4-bromo-3-methylbenzoyl)-, 1,1-dimethylethyl ester

1447727-21-0
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148672-43-9
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Yield:148672-43-9 90.5%

Reaction Conditions:

with hydrogenchloride in ethyl acetate at 0 - 30; for 18 h;Inert atmosphere;

Steps:

17.2 Step 2: Preparation of 4-bromo-3-methylbenzohydrazide (17C)

Tert-butyl 2-(4-bromo-3-methylbenzoyl)hydrazine-1-carboxylate (8.90 g, 27.1 mmol) and ethyl acetate (50 mL) were added to a reaction flask, followed by the addition of a saturated solution (40 mL) of hydrochloric acid in ethyl acetate at 0°C. The reaction solution was stirred at room temperature for 18 hours. After completion of the reaction, the reaction solution was adjusted to pH=8~9 with saturated sodium bicarbonate solution, filtered and dried to obtain 5.60 g of the title product as a white solid, yield: 90.5%.

References:

EP3919489,2021,A1 Location in patent:Paragraph 0094; 0098; 0175; 0177

148547-19-7 Synthesis