4,6-DINITRO INDOLE synthesis

5synthesis methods

Product Name:4,6-DINITRO INDOLE
CAS Number:245524-93-0
Molecular formula:C8H5N3O4
Molecular Weight:207.14

Benzene, 2-(2,2-dimethoxyethyl)-1,3,5-trinitro-

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Yield:245524-93-0 70%

Reaction Conditions:

in acetic acid;

Steps:

3 4,6-Dinitroindole

Example 3 4,6-Dinitroindole A solution of 1-(2,2-dimethoxy)ethyl-2,4,6-trinitrobenzene (117 mg, 0.388 mmol) in glacial acetic acid (1 ml) was refluxed and iron powder (69 mg, 1.17 mmol) was added. The heating source was removed and the exothermic reaction was allowed to subside. Then refluxing was continued for 30 minutes. The reaction mixture was cooled, poured into cold water, extracted with ethyl acetate, washed with water, brine and dried over anhydrous sodium sulfate. Removal of solvent gave 4,6-dinitroindole as a yellow solid (56 mg, 70%). ¹ H NMR (Acetone d6): δ 7.28 (dd, H-2); 8.12 (d, 1H, H-3); 8.85 (m, 2H, H-5 & H-7). Mass: 208 (M+ +1).

References:

US5969155,1999,A