ChemicalBook CAS DataBase List 4,6-dimethoxy-1H-1,3,5-triazin-2-one

4,6-dimethoxy-1H-1,3,5-triazin-2-one synthesis

5synthesis methods

Product Name:4,6-dimethoxy-1H-1,3,5-triazin-2-one
CAS Number:1075-59-8
Molecular formula:C5H7N3O3
Molecular Weight:157.13

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Yield: 87%

Reaction Conditions:

with potassium hydroxide in methanol for 20 h;Heating;

Steps:

5
A mixture of 2,4,6-trimethoxy-l,3,5-tnazine of formula Vila (34 g, 0.2 mol) and OH (14 g, 0.25 mol) in MeOH (150 ml) was heated up to boiling for 20 h. After cooling down to the room temperature the solvent was evaporated in vacuo and the distillation residue was put in water (50 ml). The mixture was acidified with AcOH to pH ~6 at a temperature below 15°C. The separated product was aspirated, washed with H₂0 (2 x 35 ml) and dried at the room temperature and pressure. 2-Hydroxy-4,6-dimethoxy-l,35-triazine of formula Via was obtained as a colorless crystalline substance (27 g, 87%). 1H-NMR (250 MHz, DMSO-d₆): 12.42 (bs, 1 H), 3.86 (s, 6 H; OCH₃) ppm. ¹³C-NMR (63 MHz, DMSO-d₆): 168.1, 157.3, 55.2 ppm. HPLC (200 nm): R_t = 1.475 min.

References:

ZENTIVA, K.S.;SEFKO, Martin;MAN, Stanislav;RADL, Stanislav WO2015/158317, 2015, A1 Location in patent:Page/Page column 14