4,4'-Diiodobiphenyl synthesis

11synthesis methods

Product Name:4,4'-Diiodobiphenyl
CAS Number:3001-15-8
Molecular formula:C12H8I2
Molecular Weight:406

5122-99-6 Synthesis

5122-99-6
234 suppliers
$6.00/250mg

3001-15-8
329 suppliers
$14.00/25g

Yield:3001-15-8 88%

Reaction Conditions:

with copper(II) choride dihydrate;sodium carbonate in methanol at 25; for 0.25 h;Green chemistry;

Steps:

2. General procedure for homocoupling reactions of arylboronic acids
General procedure: Arylboronic acid (0.3 mmol), CuCl2·2H2O (2.5 mg, 5 mol%), Na2CO3 (10 mol%),methanol (1 mL) were added to a vial. The reaction mixture was stirred at 25 °C inthe air for 5-15 min and was monitored by TLC. Then the reaction was quenched withtwo drops of H2O, diluted with 2 mL of ethyl acetate, and filtered over a pad ofMgSO4 and silica. The pad was rinsed with additional ethyl acetate, and the solutionwas concentrated in vacuum. The crude material was loaded onto a silica gel columnand purified by flash chromatography.

References:

Cao, Ya-Nan;Tian, Xin-Chuan;Chen, Xing-Xiu;Yao, Yun-Xin;Gao, Feng;Zhou, Xian-Li [Synlett,2017,vol. 28,# 5,art. no. ST-2016-W0543-L,p. 601 - 606] Location in patent:supporting information

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