ChemicalBook CAS DataBase List 3H-imidazo[4,5-b]pyridine-2-carboxylic acid

3H-imidazo[4,5-b]pyridine-2-carboxylic acid synthesis

4synthesis methods

Product Name:3H-imidazo[4,5-b]pyridine-2-carboxylic acid
CAS Number:97640-15-8
Molecular formula:C7H5N3O2
Molecular Weight:163.13

24638-20-8
20 suppliers
$45.00/50mg

3H-imidazo[4,5-b]pyridine-2-carboxylic acid

97640-15-8
35 suppliers
$60.00/5mg

Yield:97640-15-8 100%

Reaction Conditions:

with hydrogenchloride;potassium permanganate;sodium carbonate in water;

Steps:

b N-[(3R)-1-Azabicyclo[2.2.2]oct-3-yl]-3H-imidazo[4,5-b]pyridine-2-carboxamide Hydrochloride

Step 1004b: Preparation of 3H-imidazo[4,5-b]pyridine-2-carboxylic Acid. To a boiling solution of KMnO₄ (0.38 g, 2.4 mmol) in water (8 mL), a boiling solution of 3H-imidazo[4,5-b]pyridin-2-ylmethanol (0.20 g, 1.4 mmol) and Na₂CO₃ (0.19 g, 1.5 mmol) in water (6 mL) is added. The resulting mixture is heated at reflux for 4 hr. The hot mixture is filtered, the filtrate is cooled to rt, and the pH adjusted to 2 using conc. HCl. The resulting precipitate is collected by vacuum filtration to afford 3H-imidazo[4,5-b]pyridine-2-carboxylic acid in 100% yield: MS for C₇H₅N₃O₂: m/z 164 (M+H)⁺.

References:

US2003/73707,2003,A1