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317319-28-1

5-(CHLOROMETHYL)-2-(4-CHLOROPHENYL)-4-METHYL-1,3-THIAZOLE synthesis

3synthesis methods
-

Yield:-

Steps:

Multi-step reaction with 2 steps
1: sodium tetrahydroborate / tetrahydrofuran; methanol / 0.5 h / Reflux
2: thionyl chloride; N,N-dimethyl-formamide / dichloromethane / 4 h / 40 °C

References:

Li, Zheng;Qiu, Qianqian;Xu, Xue;Wang, Xuekun;Jiao, Lei;Su, Xin;Pan, Miaobo;Huang, Wenlong;Qian, Hai [European Journal of Medicinal Chemistry,2016,vol. 113,p. 246 - 257]

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