ChemicalBook CAS DataBase List 3-(TRIFLUOROMETHYL)-5-P-TOLYL-1H-PYRAZOLE

3-(TRIFLUOROMETHYL)-5-P-TOLYL-1H-PYRAZOLE synthesis

10synthesis methods

Product Name:3-(TRIFLUOROMETHYL)-5-P-TOLYL-1H-PYRAZOLE
CAS Number:26974-15-2
Molecular formula:C11H9F3N2
Molecular Weight:226.2

3-Buten-2-one, 1,1,1-trifluoro-4-(4-methylphenyl)-, (3E)-

96107-01-6
0 suppliers
inquiry

3-(TRIFLUOROMETHYL)-5-P-TOLYL-1H-PYRAZOLE

26974-15-2
44 suppliers
inquiry

Yield:26974-15-2 99%

Reaction Conditions:

with sodium acetate;toluene-4-sulfonic acid hydrazide in ethanol at 80; for 12 h;Schlenk technique;regioselective reaction;

Steps:

General procedure for the preparation of pyrazoles (2)

General procedure: To a 25mL Schlenk were added ketone (0.25mmol), p-toluenesulfonylhydrazide (0.275mmol, 1.1equiv), sodium acetate (0.275mmol, 1.1equiv) and EtOH (2mL). The mixture was stirred at 80°C for 12h and allowed to cool down to room temperature. After removal of the solvent, the residue was purified by column chromatography on silica gel (hexane/EtOAc) or crystallization to afford the pyrazoles 2. The analytical data are in accordance with the literature.^9,16-25

References:

Wang, Yongdong;Han, Jing;Chen, Jie;Cao, Weiguo [Tetrahedron,2015,vol. 71,# 43,p. 8256 - 8262]