3-Penten-2-one, 4-amino-3-methyl- (7CI,8CI,9CI) synthesis

6synthesis methods

Product Name:3-Penten-2-one, 4-amino-3-methyl- (7CI,8CI,9CI)
CAS Number:1113-62-8
Molecular formula:C6H11NO
Molecular Weight:113.16

815-57-6
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3-Penten-2-one, 4-amino-3-methyl- (7CI,8CI,9CI)

1113-62-8
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Yield:1113-62-8 82%

Reaction Conditions:

with ammonia at 20; for 0.5 h;

Steps:

2.1.1. 4-Amino-3-penten-2-one (3-MeAPO)

This compound was prepared according to a procedure similarto that described for APO [28]. In a 25ml round bottom flask, 3-Meacac (2.28 g, 20 mmol) was charged and cooled in the ice bathwith stirring and 25% of ammonia solution (3.5 ml) was addeddropwise, immediate white precipitation developed. After completeaddition, the mixturewas left stirred at room temperature for30 min and left stand in a stoppered flask for 48 h. The solid wastreated with diethyl ether (75 ml) and washed with distilled water(2 75 ml) and brine (75 ml). The organic portion was separatedand dried with anhydrous sodium sulfate. Evaporation of etherunder reduced pressure yields a white solid. Recrystallization fromn-heptane/ethyl acetate gave colorless needles (1.85 g, 82%), m.p.111.5e112.0 C, lit. 109-110 C [29].

References:

Seyedkatouli, Seyedabdollah;Vakili, Mohammad;Tayyari, Sayyed Faramarz;Hansen, Poul Erik;Kamounah, Fadhil S. [Journal of Molecular Structure,2019,vol. 1184,p. 233 - 245]