3-methoxyandrosta-3,5-dien-17-one synthesis
- Product Name:3-methoxyandrosta-3,5-dien-17-one
- CAS Number:57144-06-6
- Molecular formula:C20H28O2
- Molecular Weight:300.44
Yield:57144-06-6 100%
Reaction Conditions:
with p-toluenesulfonic acid hydrochloride in methanol at 35 - 45; for 5.25 h;Inert atmosphere;
Steps:
1
Under the protection of nitrogen, 100 ml of methanol, 100 g of 4-androstenedione and 10 g of p-toluenesulfonic acid hydrochloride were added to the reaction flask, and the temperature of the system was adjusted to 35 to 40 ° C. 100 ml of trimethyl orthoformate was added dropwise About 15min, after the drop completely, the reaction in 35 ~ 45 5h, the reaction is completed, with triethylamine adjusted PH value to 8 ~ 9, concentrated under reduced pressure to dry, add water 1000ml, stirring and dispersing, pumping, washing to 3-methoxyandrosta-3,5-diene-17-one 100 g, mass yield: 100%, HPLC purity: 98%.
References:
CN104327142,2016,B Location in patent:Paragraph 0023
