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23904-02-1

3-Methoxy-6-Nitro-2-Picoline synthesis

2synthesis methods
-

Yield:-

Reaction Conditions:

with nitric acid in sulfuric acid;

Steps:

A.9.b Example A9

b) The methoxypyridine (24.2 g) was dissolved in concentrated sulphuric acid (100 ml) and treated with a mixture of concentrated nitric acid (16.5 ml) and concentrated sulphuric acid (20.0 ml) which was added dropwise with stirring at 5° C., to give 3-methoxy-2-methyl-6-nitropyridine, m.p. 96°-98° C.

References:

US5464781,1995,A

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