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ChemicalBook CAS DataBase List 3-hydroxypiperidin-2-one
19365-08-3

3-hydroxypiperidin-2-one synthesis

10synthesis methods
-

Yield:-

Steps:

Multi-step reaction with 3 steps
1: 90 percent / NaOH; alumina / toluene / 1.5 h / Heating
2: 60 percent / iso-amyl nitrite; glacoal AcOH / CHCl3 / 0.25 h / Heating
3: 22 percent / H2O / Rh2(OAc)4 / tetrahydrofuran / 10 h / 35 °C

References:

Hutchinson, Ian S;Matlin, Stephen A;Mete, Antonio [Tetrahedron,2002,vol. 58,# 16,p. 3137 - 3143]

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