3-Fluorobenzonitrile synthesis

12synthesis methods

Product Name:3-Fluorobenzonitrile
CAS Number:403-54-3
Molecular formula:C7H4FN
Molecular Weight:121.11

456-48-4 Synthesis

456-48-4
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403-54-3
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$7.00/5g

Yield:403-54-3 90%

Reaction Conditions:

with hydroxylamine hydrochloride in methanol;water at 20; for 18 h;Irradiation;

Steps:

3.1. General method for the synthesis of nitrile 3
General procedure: A round bottom flask was charged with a mixture of benzaldehyde 1(1.0 mmol), NH2OH.HCl 2 (1.5 mmol), Cog-C3N4 (20 mg) in H2O/MeOH (1:1, 5 mL) and stirred under the visible light condition at roomtemperature for 14-20 h. After completion of the reaction (monitored by TLC), the catalyst was filtered and added EtOAc (10 mL). Remaining organic layer was washed with brine (2×5 mL) and distilled water(1×10 mL) and dried over anhydrous sodium sulfate. Solvent was evaporated under reduced pressure to afford the crude residue, which was further purified by flash chromatography, EtOAc/n-hexane: 10:90 to obtain the analytically pure product 3

References:

Verma, Fooleswar;Shukla, Prashant;Bhardiya, Smita R.;Singh, Manorama;Rai, Ankita;Rai, Vijai K. [Catalysis Communications,2019,vol. 119,p. 76 - 81]

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