3-(DIMETHYLAMINO)PROPYL CHLORIDE HYDROCHLORIDE synthesis
- Product Name:3-(DIMETHYLAMINO)PROPYL CHLORIDE HYDROCHLORIDE
- CAS Number:5407-04-5
- Molecular formula:C5H13Cl2N
- Molecular Weight:158.07
124-40-3
510 suppliers
$18.00/100ml
107-05-1
406 suppliers
$16.80/100ML
5407-04-5
347 suppliers
$6.00/25g
Yield:5407-04-5 90%
Reaction Conditions:
with diatomaceous earth in toluene at 45; for 10 h;Reagent/catalyst;Temperature;Solvent;
Steps:
1-3 Example 3
A preparation method of N,N-dimethylaminochloropropane hydrochloride, the specific steps are as follows:1) Put 50.0 g of chloropropene and 150 g of toluene into a four-port reaction flask, and stir.Add 1.0g of diatomite as catalyst, and 38g of dimethylamine gas at 45.After holding the reaction at 45 for 10h, the reaction is terminated. At this time, the gas phase tracking detection analysis analyzes the content of chloropropene ≤ 2%;2) The reaction product in step 1) is distilled under reduced pressure, and 42.1 g of toluene and unreacted vinyl chloride are recovered, washed with 100 g of water, and filtered to remove the catalyst diatomaceous earth. Hydrochloric acid is added dropwise to the organic layer to adjust the pH to 2 3. Reaction and reflux with water at 112 for 12h, lower to normal temperature, filter and dry to obtain 93.0g of N,N-dimethylaminochloropropane hydrochloride, purity 99.1%, molar yield 90.0%.
References:
Henan Yuchen Pharmaceutical Co., Ltd.;Li Shanshan;Wei Liqiang;Zhang Yuanfeng;Cheng Lihong;Luo Ming;Zhou Jinlong;Zhang Ying CN111153807, 2020, A Location in patent:Paragraph 0028-0039
3179-63-3
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$10.60/1gm:
5407-04-5
347 suppliers
$6.00/25g
124-40-3
510 suppliers
$18.00/100ml
627-30-5
322 suppliers
$9.00/1g
5407-04-5
347 suppliers
$6.00/25g
50-00-0
861 suppliers
$10.00/25g
6276-54-6
375 suppliers
$21.00/25g
5407-04-5
347 suppliers
$6.00/25g