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16728-63-5

3-(CYCLOHEXYLOXY)PROPAN-1-AMINE synthesis

3synthesis methods
-

Yield:-

Steps:

Multi-step reaction with 4 steps
1: LAH / diethyl ether / 0 °C
2: Et3N / dimethylformamide / 1 h / 0 °C
3: NaN3 / dimethylformamide; H2O / 60 - 70 °C
4: H2O, Ph3P / tetrahydrofuran / Ambient temperature

References:

Takeuchi, Kumiko;Kohn, Todd J.;True, Timothy A.;Mais, Dale E.;Wikel, James H.;Utterback, Barbara G.;Wyss, Virginia L.;Jakubowski, Joseph A. [Journal of Medicinal Chemistry,1998,vol. 41,# 27,p. 5362 - 5374]

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