3-CYANOPHENYL CYCLOPROPYL KETONE synthesis
- Product Name:3-CYANOPHENYL CYCLOPROPYL KETONE
- CAS Number:898789-86-1
- Molecular formula:C11H9NO
- Molecular Weight:171.2
![3-[Cyclopropyl(hydroxy)methyl]benzonitrile](/CAS/20140525/GIF/CB22691709.gif)
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Yield:898789-86-1 100%
Reaction Conditions:
with 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione in ethyl acetate at 20 - 80; for 2 h;
Steps:
2.b
2-Iodoxybenzoic acid (IBX) was added to a solution of 3-(cyclopropyl(hydroxy)methyl)benzonitrile (171 mg, 1 mmol) in EtOAc (5 ml) at room temperature and stirred at 80 °C for 2 hours. After cooling to 0 °C, the precipitated materials were filtered off and washed with EtOAc (3 ml x 2), then the filtrate was evaporated under reduced pressure. The residue was purified by column chromatography on silica (EtOAc/Hexanes 5/95-30/70) to give 3-(cyclopropanecarbonyl)benzonitrile (225 mg, 100 %)
References:
WO2008/150470,2008,A1 Location in patent:Page/Page column 82
24964-64-5
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