3-Chloropropionyl chloride synthesis

12synthesis methods

Product Name:3-Chloropropionyl chloride
CAS Number:625-36-5
Molecular formula:C3H4Cl2O
Molecular Weight:126.97

3-Chloropropionyl chloride is produced by reaction of acrylic acid with hydrogen chloride and phosgene in the presence of, for example, dimethylformamide as catalyst, or by reaction of propiolactone with thionyl chloride.

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625-36-5
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Yield:625-36-5 98.5%

Reaction Conditions:

with bis(trichloromethyl) carbonate in toluene at 25; for 8 h;Reagent/catalyst;Temperature;

Steps:

1 Preparation of 3-chloropropionyl chloride (II).

In a 1000 ml reaction flask,52.6 g of 3-chloropropionic acid (0.485 mol)500 ml toluene,72.0 g triphosgene (0.485 mol),Slowly warmed to 25 , incubated for 8h,The material is a transparent liquid, and then recovering the toluene under reduced pressure,Evaporated to give the product (II) 60.7g, the yield was 98.5%500ml of chloroform was added and dissolved with stirring at room temperature to give a pale yellow transparent liquid for the condensation reaction below.

References:

CN106565607,2017,A Location in patent:Paragraph 0005; 0027; 0028; 0029; 0030

79-10-7 Synthesis