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ChemicalBook CAS DataBase List 3-CHLORO-5-FLUOROBENZALDEHYDE
90390-49-1

3-CHLORO-5-FLUOROBENZALDEHYDE synthesis

5synthesis methods
-

Yield:-

Steps:

Multi-step reaction with 6 steps
1: 62 percent / (NH4)2S / methanol / 5 h / Heating
2: 1.) HNO2, 2.) CuCl2, CuCl, 12percent aq. HCl / 1.) 0 deg C, 2.) 60 deg C, 1 h
3: 81 percent / Fe, HCl (gas) / ethanol
4: 65 percent / aq. HBF4, NaNO2 / -5 °C
5: 25 percent / Heating
6: 73 percent / MnO2 / benzene / 24 h / Heating

References:

Meindl;Von Angerer;Schonenberger;Ruckdeschel [Journal of Medicinal Chemistry,1984,vol. 27,# 9,p. 1111 - 1118]

FullText

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