ChemicalBook CAS DataBase List 3-CHLORO-5,5-DIMETHYL-2-CYCLOHEXEN-1-ONE

3-CHLORO-5,5-DIMETHYL-2-CYCLOHEXEN-1-ONE synthesis

7synthesis methods

Product Name:3-CHLORO-5,5-DIMETHYL-2-CYCLOHEXEN-1-ONE
CAS Number:17530-69-7
Molecular formula:C8H11ClO
Molecular Weight:158.63

79-37-8
472 suppliers
$17.67/10gm:

126-81-8 Synthesis

126-81-8
409 suppliers
$5.00/10g

3-CHLORO-5,5-DIMETHYL-2-CYCLOHEXEN-1-ONE

17530-69-7
73 suppliers
$47.29/5g

Yield: 15.7 g (92%)

Reaction Conditions:

in chloroform

Steps:

1.1 Preparation of 3-chloro-5,5-dimethylcyclohex-2-en-1-one
Step 1 Preparation of 3-chloro-5,5-dimethylcyclohex-2-en-1-one The title compound was prepared using the method of Clark and Heathcock. J. Org. Chem., 1976, 41, 636. To a suspension of dimedone (15.0 g, 107 mmol) in chloroform (40 ml) was added slowly oxalyl chloride (27.2 g, 214 mmol). The addition was accompanied by vigorous evolution of gas. After stirring at room temperature for 10 minutes, the slurry was refluxed for 20 minutes to give a yellow solution which was evaporated and distilled to give 15.7 g (92%) of chloroenone as a colorless liquid, bp 72° (5 mm).

References:

Rorer Pharmaceutical Corporation US4892884, 1990, A

126-81-8 Synthesis

126-81-8
409 suppliers
$5.00/10g

17530-69-7
73 suppliers
$47.29/5g

References

3471-13-4 Synthesis