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ChemicalBook CAS DataBase List 3-BROMO-N-HYDROXY-BENZAMIDINE
173406-70-7

3-BROMO-N-HYDROXY-BENZAMIDINE synthesis

2synthesis methods
-

Yield:173406-70-7 100%

Reaction Conditions:

with hydroxylamine hydrate in ethanol at 90; for 1 h;Sealed tube;

Steps:

4.1.4. General procedure for the synthesis of amidoximes (39e52)

General procedure: In a pressurized sealed vial, aqueous hydroxylamine 50% w/w (4equiv) was added to a stirred solution of the appropriate carbonitrile(1 equiv) in absolute ethanol. The resulting mixture washeated at 90 C for 1 h. The solvent was then evaporated to drynessproviding the desired amidoxime quantitatively, which was usedwithout further purification.

References:

Quadri, Marta;Silnovi?, Almin;Matera, Carlo;Horenstein, Nicole A.;Stokes, Clare;De Amici, Marco;Papke, Roger L.;Dallanoce, Clelia [European Journal of Medicinal Chemistry,2018,vol. 160,p. 207 - 228]

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