3-Bromo-6-fluoroindole synthesis
- Product Name:3-Bromo-6-fluoroindole
- CAS Number:1094754-90-1
- Molecular formula:C8H5BrFN
- Molecular Weight:214.03
399-51-9
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Yield:1094754-90-1 100%
Reaction Conditions:
with N-Bromosuccinimide in N,N-dimethyl-formamide at 20; for 2 h;
Steps:
52.1 Step : 3-bromo-6-fluoro-1H-indole (38'-1)
Dissolve 6-fluoroindole (1g) in N,N-dimethylformamide (8mL), add N-bromosuccinimide (1.38g) in batches, and stir at room temperature for 2 hours. Add to saturated sodium chloride solution in batches, extract with ethyl acetate, concentrate the organic phase to dryness, and chromatograph with petroleum ether to obtain the pink oily 3-bromo-6-fluoro-1H-indole (38'-1 ) 1.6g, yield 100%.
References:
CN112724127,2021,A Location in patent:Paragraph 0952-0956