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ChemicalBook CAS DataBase List 3-BROMO-5-NITROBENZALDEHYDE
355134-13-3

3-BROMO-5-NITROBENZALDEHYDE synthesis

2synthesis methods
-

Yield: 88%

Reaction Conditions:

with oxygen;caesium carbonate in water for 2 h;Reflux;

Steps:

General procedure
General procedure: All reactions were performed in a glass flask slurry reactor connected to an O2 tube for atmosphere control and a condenser for reflux condition. A mixture of alcohol (1mmol), Cs2CO3 (0.5mmol) and 2Au/1CuO-ZnO (0.05g) in water was stirred under oxygen atmosphere in a slurry reactor at total reflux condition. Then the catalyst was recovered by filtration, washed two times with 5ml hot EtOAc, and dried for consecutive reaction runs. The filtrate was quenched with 2M HCl aqueous solution, extracted with EtOAc three times and dried over anhydrous MgSO4. Evaporation of the solvent followed by column chromatography on silica gel afforded the pure products (Table3).

References:

Albadi, Jalal;Alihoseinzadeh, Amir;Razeghi, Abdolhosein [Catalysis Communications,2014,vol. 49,p. 1 - 5]

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