3-BROMO-5-(2-TRIMETHYLSILYL)ETHYNYL)PYRIDINE synthesis
- Product Name:3-BROMO-5-(2-TRIMETHYLSILYL)ETHYNYL)PYRIDINE
- CAS Number:639011-64-6
- Molecular formula:C10H12BrNSi
- Molecular Weight:254.2
233770-01-9
187 suppliers
$8.00/250mg
1066-54-2
465 suppliers
$9.00/10g
639011-64-6
17 suppliers
inquiry
Yield:639011-64-6 99%
Reaction Conditions:
with triethylamine;bis-triphenylphosphine-palladium(II) chloride in acetonitrile; for 16 h;
Steps:
22
Add trimethylsilylacetylene (54. 6 mL, 389. 4 mmol) to a stirred mixture of 3- bromo-5-iodopyridine (100 g, 354 mmol) in triethylamine (800 mL) and acetonitrile (800 mL). Purge the system with nitrogen and add bis (triphenylphosphine'palladium (II) dichloride (3. 54 mmol, 2. 48 g) and stir for 16 h. Concentrate and suspend the residue in 1800 mL of hexanes. Stir for 2 h, filter and concentrate to give the title compound as a brown solid (92 g, 99%). 1H NMR (300 MHz, CDCl3) 6 8. 54 (m, 2 H), 7. 58 (m, 1 H), 0. 22 (s, 9 H) ; LC-MS (ES) : m/z = 254, 256 [M+H] +.
References:
WO2005/94822,2005,A1 Location in patent:Page/Page column 36
625-92-3
491 suppliers
$6.00/10g
639011-64-6
17 suppliers
inquiry