3-benzyl-6-bromo-2-methoxyquinoline synthesis
- Product Name:3-benzyl-6-bromo-2-methoxyquinoline
- CAS Number:654655-69-3
- Molecular formula:C17H14BrNO
- Molecular Weight:328.2
654655-68-2
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$5.00/250mg
67-56-1
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$7.29/5ml-f
124-41-4
690 suppliers
$12.00/25g
654655-69-3
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$8.00/250mg
Yield:654655-69-3 89%
Reaction Conditions:
for 8 h;Heating / reflux;
Steps:
B
Preparation of 3 -Benzyl- 6-bromo-2-m ethoxy-q u m olin e; To a stirred solution of compound 3-Benzyl-6-bromo-2-chloro-qumolme (5 O g, 15 0 mmol) m dry methanol (50 ml) was added sodium methoxide (30% w/v m methanol, 15.0 ml, 84 0 mmol) and the contents were heated under reflux for 8 h The volatiles were removed under reduced pressure, poured into ice-water mixture, the solid separated out was filtered, washed with water and dried to furnish the compound (4 4 g, 89%) as an off-white solid, Mp 83-850C 1H NMR (400 MHz, CDCl3). δ 4.02 (s, 2 H), 4 07 (s, 3 H), 7 20-7 26 (m, 3 H), 7 29-7 34 (m, 2 H), 7 47 (s, 1 H), 7 60 (dd, J = 8 0, 4 0 Hz, 1 H), 7 60 (dd, J = 8 8, 2 2 Hz, 1 H), 7.73 (d, J= 2.0 Hz, 1 H) (M+H)+= 328, 330
References:
CHATTOPADHYAYA, Jyoti;UPADHAYAYA, Ram Shankar WO2009/91324, 2009, A1 Location in patent:Page/Page column 23
654655-68-2
115 suppliers
$5.00/250mg
124-41-4
690 suppliers
$12.00/25g
654655-69-3
221 suppliers
$8.00/250mg
654655-80-8
32 suppliers
$390.00/10 mg
654655-69-3
221 suppliers
$8.00/250mg
2752-87-6
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845533-86-0
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654655-69-3
221 suppliers
$8.00/250mg
654655-80-8
32 suppliers
$390.00/10 mg
654655-69-3
221 suppliers
$8.00/250mg
10320-49-7
115 suppliers
$30.00/250mg