ChemicalBook CAS DataBase List 3-acetyl-4-hydroxy-2-benzopyrone

3-acetyl-4-hydroxy-2-benzopyrone synthesis

8synthesis methods

Product Name:3-acetyl-4-hydroxy-2-benzopyrone
CAS Number:2555-37-5
Molecular formula:C11H8O4
Molecular Weight:204.18

1076-38-6
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$24.00/100g

64-19-7 Synthesis

64-19-7
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$10.00/25ML

2555-37-5
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$45.00/100mg

Yield:2555-37-5 92%

Reaction Conditions:

with trichlorophosphate for 1 h;Schlenk technique;Inert atmosphere;Reflux;

Steps:

General procedure for synthesis of 3-acetyl-4-hydroxycoumarin (1):

In a round bottom flask, 3 g (18.6 mmol) of 4-hydroxycoumarin, 16 mL of acetic acid (27.9 mmol) (solvent and reagent at a time) and 5.6 mL (60 mmol) of phosphorus oxychloride are added. The reaction was refluxed under continuous stirring for 1 h. Control of the evolution of the reaction by thin layer chromatography (TLC) (eluent: hexane-ethanol 80:20) revealed the formation of a single compound. At the end of the reaction, the product was filtered, recrystallized from ethanol, dried and recovered (Scheme-I). Yield: 92 %; m.p.: 225 °C; FT-IR (KBr, ν_max, cm^-1): 3185 (O-H); 1700 (CO lactone); ¹H NMR (400 MHz, DMSO-d₆) ppm δ: 2.45 (s, 3H, CO-CH₃); 7.15-7.92 (m, 4H, H_arom), 17.72 (s, OH). ¹³C NMR (100 MHz, DMSO-d₆) in ppm δ: 32.36 (H₃C-CO); 102.32 (aryl-C=C-OH); 115.91, 122.98, 125.66 (C_arom) 132.95 (O-C_arom); 157.54 (CO-O); 162.92 (C=C-OH); 176.70 (H₃C-CO). Elemental analysis % calcd. (found) for C₁₁H₈O₄: C, 64.707 (64.60); H, 3.949 (4.09); N, 8.123 (8.07).

References:

Mnasri, Aziza;Chakchouk-Mtibaa;Al-Ayed, Abdullah Sulaiman;Jemmali, Mosbah;Mellouli;Bilel, Hallouma;Hamdi, Naceur [Asian Journal of Chemistry,2019,vol. 31,# 7,p. 1609 - 1616]

1076-38-6
539 suppliers
$24.00/100g

75-36-5 Synthesis