ChemicalBook CAS DataBase List 3,5-Difluoroaniline

3,5-Difluoroaniline synthesis

11synthesis methods

Product Name:3,5-Difluoroaniline
CAS Number:372-39-4
Molecular formula:C6H5F2N
Molecular Weight:129.11

461-96-1 Synthesis

461-96-1
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$6.00/10g

372-39-4
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$16.00/5g

Yield:372-39-4 94%

Reaction Conditions:

with copper(I) oxide;1-D-O-Methyl-chiro-inositol;ammonia;sodium hydroxide in water at 100; for 12 h;

Steps:

1.5. General procedures for ammonization of aryl bromides (Table 4)

General procedure: A 25 mL hydrothermal synthesis reactor equipped with a magnetic stirring bar was charged with sodium hydroxideand 5 mL 25 % ammonia, and then stirred at ambient temperature. After the dissolution of cuprous oxide, L-Que andaryl bromides were added. The reaction mixture was stirred at 100 oC until the hydrolysis of aryl iodides completes byTLC analysis. Then the reaction mixture was cooled to ambient temperature, diluted by water, and extracted with ethylacetate. The combined organic phase was dried over anhydrous magnesium sulfate and the solvent was removed underreduced pressure. The crude products were purified by flash column chromatography on silica gel to afford the desiredproduct.

References:

Bao, Xuefei;Chen, Guoliang;Dong, Jinhua;Du, Fangyu;Li, Hui;Liang, Xinjie;Wu, Ying;Zhang, Yongsheng [Tetrahedron Letters,2020] Location in patent:supporting information