3-(5-CHLORO-THIOPHEN-2-YL)-3-OXO-PROPIONITRILE synthesis

4synthesis methods

Product Name:3-(5-CHLORO-THIOPHEN-2-YL)-3-OXO-PROPIONITRILE
CAS Number:71683-01-7
Molecular formula:C7H4ClNOS
Molecular Weight:185.63

35475-03-7 Synthesis

35475-03-7
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75-05-8 Synthesis

75-05-8
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3-(5-CHLORO-THIOPHEN-2-YL)-3-OXO-PROPIONITRILE

71683-01-7
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Yield:-

Reaction Conditions:

with sodium methylate in methanol;Inert atmosphere;Reflux;Claisen Condensation;

Steps:

5.2.4 Synthesis of 3-(5-halide thiophene-2-yl)-3-oxopropanenitrile

General procedure: 5-halide thiophene-2-carboxylate (1equiv) was solved under inert conditions in absolute acetonitrile, and sodium methoxide (2equiv, freshly prepared) was added. The reaction stirred under reflux conditions overnight and was diluted with purified water, afterwards. The aqueous phase was extracted with dichloromethane. The organic layer was dried over MgSO₄, filtrated and the solvent was evaporated under reduced pressure. The white solid phase was used without any further purification.

References:

Hauck, Stefanie;Hiesinger, Kerstin;Khageh Hosseini, Sabrina;Achenbach, Janosch;Biondi, Ricardo M.;Proschak, Ewgenij;Z?rnig, Martin;Odadzic, Dalibor [Bioorganic and Medicinal Chemistry,2016,vol. 24,# 22,p. 5717 - 5729]

24065-33-6 Synthesis