ChemicalBook CAS DataBase List 3,4-DICHLOROBENZO[B]THIOPHENE-2-CARBONYL CHLORIDE

3,4-DICHLOROBENZO[B]THIOPHENE-2-CARBONYL CHLORIDE synthesis

4synthesis methods

Product Name:3,4-DICHLOROBENZO[B]THIOPHENE-2-CARBONYL CHLORIDE
CAS Number:34576-86-8
Molecular formula:C9H3Cl3OS
Molecular Weight:265.54

3752-25-8
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3,4-DICHLOROBENZO[B]THIOPHENE-2-CARBONYL CHLORIDE

34576-86-8
15 suppliers
$58.00/100mg

Yield:-

Reaction Conditions:

with pyridine;thionyl chloride at 100; for 3 h;

Steps:

General Procedure for Synthesis of 3-chloro-subbenzo[b]thiophene-2-carbonyl Chloride (1a-h)

General procedure: 3-Chloro-sub-benzo[b]thiophene-2-carbonyl chlorides (1a-h) were previously synthesized using reported synthetic method [17]. A mixture of appropriate cinnamic acid (0.01 M), thionyl chloride (2 eq.) in pyridine (1 eq.) was heated at 100 °C for 3hrs. TLC was checked for the completion of reaction. After completion of the reaction, excess of thionyl chloride was distilled under vacuum. After this in oily material, dichloromethane was added and stirred well. Again dichloromethane was distilled. The desired product was yellow oil, which was stored under nitrogen atmosphere.

References:

Ghodasara;Vaghasiya;Gothaliya;Shah [Letters in drug design and discovery,2014,vol. 11,# 3,p. 349 - 354]

704-96-1 Synthesis