ChemicalBook CAS DataBase List 3,4,5-Trimethoxyaniline

3,4,5-Trimethoxyaniline synthesis

10synthesis methods

Product Name:3,4,5-Trimethoxyaniline
CAS Number:24313-88-0
Molecular formula:C9H13NO3
Molecular Weight:183.2

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24313-88-0
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Yield:24313-88-0 96.4%

Reaction Conditions:

with hydrazine hydrate;palladium 10% on activated carbon in ethanol; for 1 h;Reflux;

Steps:

B9.B

Step B / Intermediate B9: 3,4,5-trimethoxyani.ineTo a solution of 1 ,2,3-trimethoxy-5-nifrobenzene (6.64 g, 31.2 mrnol ) in ethanol (250 mL) was added palladium on carbon (10 %, 300 mg) and hydrazine hydrate (85 %, 5.7 mL). After emission of gas has ceased, the reaction mixture was heated at refluxed for 1 hour, cooling to room temperature, filtered and evaporated to afford the product 3,4,5-trimethoxyaniline as a white solid (5.5 g, yield 96.4 %). H NMR (400 MHz, DMSO-d6) δ ppm 5.86 (s, 2H), 4.82 (br, 2H), 3.64 (s, 6H), 3.50 (s, 3H).

References:

WO2012/92880,2012,A1 Location in patent:Page/Page column 60