ChemicalBook CAS DataBase List 3,3',4,4'-TETRAMETHYL BENZOPHENONE

3,3',4,4'-TETRAMETHYL BENZOPHENONE synthesis

9synthesis methods

Product Name:3,3',4,4'-TETRAMETHYL BENZOPHENONE
CAS Number:4659-48-7
Molecular formula:C17H18O
Molecular Weight:238.32

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Yield: 93.8%

Reaction Conditions:

with iron(III) chloride;sulfuric acid at 5 - 10; for 0.8 h;Reagent/catalyst;Temperature;

Steps:

2
A mixture of o-xylene 106g (0.998mol), ferric chloride 130g (0.785mol) and the mass concentration of 98% concentrated sulfuric acid 10g added to the reaction flask. The 160g (1.029mol) of carbon tetrachloride was added dropwise to the reaction flask. After completion of the dropwise addition, incubated 0.8 hours at a temperature of 5-10 °C condition, the disappearance of the HPLC detector o-xylene, the reaction can be terminated.Washed with water and ferric chloride excess concentrated sulfuric acid, until pH = 4 ~ 5, a reduced pressure to recover the remaining carbon tetrachloride to give an oil 160g.500g residual oil was recrystallized from ethanol, to give 3,3',4,4'-tetramethylbenzophenone 111.6g, 93.8% yield, 98.4% purity.

References:

JIANGSU AOLUNDA HIGH-TECH INDUSTRY CO., LTD;WAN, LIBING;CHEN, HAIQUN;ZHANG, YIN;CHEN, PANQIANG;CHEN, LYU CN104557501, 2016, B Location in patent:Paragraph 0024; 0025